Urinary Organic Acids in Infant Malnutrition
نویسندگان
چکیده
منابع مشابه
Targeted Exposomics: Profiling Urinary Organic Acids
Measuring the exposome or totality exposures over individuals’ lifetime, offers new insight into exposure-response relationships (biological epidemiology) by determining and differentiating the causal pathways (exposure biology) and reactive pathways (systems biology) in chronic human disease. Through the application of discovery-based omics and targeted methodologies to measure the exposome, e...
متن کاملUrinary organic acids in man. I. Normal patterns.
We studied qualitative pattern of urinary acidic metabolites excreted by normal persons. The results provide a basis on which to compare results for patients with potentially abnormal organic acidurias. A series of urinary polyhydroxy (aldonic and deoxyaldonic) acids has been identified. Most of these compounds have not been previously reported in human urine, except in connection with the pres...
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Part 1 of this series focused on urinary organic acids as markers of detoxification; part 2 focuses on dysbiosis markers. Intestinal microbial growth is accompanied by the release of products of their metabolism that may be absorbed and excreted in urine. Several organic acids are known to be specific products of bacterial metabolic action on dietary polyphenols or unassimilated amino acids or ...
متن کاملUrinary organic acids: isolation and quantification for routine metabolic screening.
A method for isolating organic acids from acidified urine on an equivolume mixture of Porapak Q and Porapak T is described, and results are compared with extraction with ethyl acetate and ion exchange on DEAE-Sephadex. Average recoveries of 14C-labeled oxalic acid, lactic acid, succinic acid, alpha-ketoglutaric acid, citric acid, and cinnamic acid were equal to or better than those obtained wit...
متن کاملClinical applications of urinary organic acids. Part I: Detoxification markers.
Modern instrumentation allows the measurement of organic acids in urine in their physiological concentration ranges. Eight of the compounds that are reported can serve as markers for specific toxicant exposure or detoxification challenges. Xylene exposure causes elevation of 2-methylhippurate, and orotic acid elevation reveals ammonia challenge that exceeds the capacity of the urea cycle. Gener...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1998
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199809000-00020